Nigerian Journal of Clinical Practice

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 21  |  Issue : 7  |  Page : 894--900

Midkine levels and its relationship with atherosclerotic risk factors in essential hypertensive patients


S Guzel1, FB S Cinemre2, EC Guzel3, V Kucukyalcin1, AR Kiziler4, C Cavusoglu5, T Gulyasar6, H Cinemre7, B Aydemir8 
1 Department of Medical Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
2 Department of Medical Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey
3 Department of Family Physician, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
4 Department of Biophysics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
5 Department of Medical Biochemistry, Silivri Anatolia Hospital, Istanbul, Turkey
6 Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey
7 Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
8 Department of Biophysics, Faculty of Medicine, Sakarya University, Sakarya, Turkey

Correspondence Address:
Prof. F B S Cinemre
epartment of Medical Biochemistry, Faculty of Medicine, Sakarya, University, Adapazari, Sakarya 54290
Turkey

Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 ± 6.8 ng/mL vs. 18.39 ± 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 ± 34.06 μg/dL and 172.55 ± 45.47μg/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B12levels (r = −0.298, P < 0.023, r = −0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.


How to cite this article:
Guzel S, S Cinemre F B, Guzel E C, Kucukyalcin V, Kiziler A R, Cavusoglu C, Gulyasar T, Cinemre H, Aydemir B. Midkine levels and its relationship with atherosclerotic risk factors in essential hypertensive patients.Niger J Clin Pract 2018;21:894-900


How to cite this URL:
Guzel S, S Cinemre F B, Guzel E C, Kucukyalcin V, Kiziler A R, Cavusoglu C, Gulyasar T, Cinemre H, Aydemir B. Midkine levels and its relationship with atherosclerotic risk factors in essential hypertensive patients. Niger J Clin Pract [serial online] 2018 [cited 2022 Aug 8 ];21:894-900
Available from: https://www.njcponline.com/article.asp?issn=1119-3077;year=2018;volume=21;issue=7;spage=894;epage=900;aulast=Guzel;type=0