Nigerian Journal of Clinical Practice

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 21  |  Issue : 7  |  Page : 870--874

Train-of-four guard-controlled sugammadex reversal in patients with multiple sclerosis


RA Altunbay1, N Sinikoglu2, M Bagci2 
1 Department of Anesthesiology, Kars State Hospital, Kars, Turkey
2 Department of Anesthesiology, Bagcilar Training and Research Hospital, Istanbul, Turkey

Correspondence Address:
Dr. R A Altunbay
Department of Anesthesiology, Kars State Hospital, Kars
Turkey

Objective: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating autoimmune disease of the central nervous system. It is known that the disease, which is manifested by a wide variety of symptoms, may exacerbate after anesthesia and show different responses to muscle relaxants in the normal population. It is planned to measure train-of-four (TOF) values of MS patients to be operated under general anesthesia before sugammadex application. Materials and Methods: With the approval of the local ethics committee of the University of Health Sciences Bagcilar Training and Research Hospital and with written consents of participants, we anesthetized ten patients (from April 2014 to March 2017) with MS and ten American Society of Anesthesiologists I-III patients without MS. Neuromuscular conduction was assessed by the acceleromyometric method using a TOF-Guard apparatus (Organon, Holland). The patients were extubated after recovery of TOF higher than 0.9. The primary efficacy variable was the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9. Results: The demographic characteristics of both groups, the type and duration of surgery and anesthesia applied, and the temperature of the operation room were similar. Similar characteristics of both groups were of concern for postoperative residual paralysis, and therefore we did not notice any difference between time to TOF >90/s for both groups. Conclusion: Sugammadex and TOF patients will increase patient safety in general anesthesia practice.


How to cite this article:
Altunbay R A, Sinikoglu N, Bagci M. Train-of-four guard-controlled sugammadex reversal in patients with multiple sclerosis.Niger J Clin Pract 2018;21:870-874


How to cite this URL:
Altunbay R A, Sinikoglu N, Bagci M. Train-of-four guard-controlled sugammadex reversal in patients with multiple sclerosis. Niger J Clin Pract [serial online] 2018 [cited 2022 May 25 ];21:870-874
Available from: https://www.njcponline.com/article.asp?issn=1119-3077;year=2018;volume=21;issue=7;spage=870;epage=874;aulast=Altunbay;type=0