Nigerian Journal of Clinical Practice

ARTICLE
Year
: 2009  |  Volume : 12  |  Issue : 4  |  Page : 355--358

The role of blood transfusion on the prevalence of hepatitis C virus antibodies in children with sickle cell anaemia in Enugu, South East Nigeria


OS Ejiofor, BC Ibe, IJ Emodi, AN Ikefuna, GC Ilechukwu, G Emechebe, C Ilechukwu 
 Department of Paediatrics, Amaku General Hospital Awka, Anambra State, Nigeria

Correspondence Address:
O S Ejiofor
Department of Paediatrics, Amaku General Hospital Awka, Anambra State, Nigeria

BACKGROUND: The hepatitis C Virus (HCV) has become an important cause of chronic liver disease and liver cancer worldwide. Blood transfusion is one of the important modes of transmission. There is need to study the prevalence among those at risk such as sickle cell anaemia (SCA) patients. Such information will broaden knowledge of the problem among SCA patients transfused with blood in this part of the country. OBJECTIVE: To determine the prevalence of HCV antibodies among children with SCA transfused with blood in Enugu, compared with their non transfused counterparts as well as the roles of blood transfusion and traditional surgery in the prevalence ofHCV infection. METHODOLOGY: The study was conducted among 269 children with SCA attending the paediatrics sickle cell clinic at University of Nigeria Teaching Hospital (UNTH) Enugu, with 136 transfused SCA patients as subjects and 133 age and sex matched non-transfused SCA who served as controls. RESULTS: The results showed an HCV antibody prevalence of 6.6% among the transfused and 5.3% among the non-transfused (controls) SCA patients (P = 0.610). There was positive association between number of transfusions and HCV seropositiviy, such that those who had received 4 or more units ofblood had a prevalence rate of more than 50% (P = 0.001). The influence of scarifications on the prevalence of antibodies to HCV (antiHCV) for the non transfused (controls) was statistically significant (P = 0.001). CONCLUSION: HCV infection is not uncommon in children with SCA. The prevalence of HCV infection in transfused SCA patients is not significantly higher than their age/sex matched controls.


How to cite this article:
Ejiofor O S, Ibe B C, Emodi I J, Ikefuna A N, Ilechukwu G C, Emechebe G, Ilechukwu C. The role of blood transfusion on the prevalence of hepatitis C virus antibodies in children with sickle cell anaemia in Enugu, South East Nigeria.Niger J Clin Pract 2009;12:355-358


How to cite this URL:
Ejiofor O S, Ibe B C, Emodi I J, Ikefuna A N, Ilechukwu G C, Emechebe G, Ilechukwu C. The role of blood transfusion on the prevalence of hepatitis C virus antibodies in children with sickle cell anaemia in Enugu, South East Nigeria. Niger J Clin Pract [serial online] 2009 [cited 2022 May 17 ];12:355-358
Available from: https://www.njcponline.com/article.asp?issn=1119-3077;year=2009;volume=12;issue=4;spage=355;epage=358;aulast=Ejiofor;type=0