Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 3144   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 25  |  Issue : 9  |  Page : 1418-1423

A novel combined index of D-dimer, fibrinogen, albumin, and platelet (FDAPR) as mortality predictor of COVID-19


1 Department of Medical Biochemistry, Medical Faculty of Tekirdağ Namık Kemal University, Tekirdağ, Turkey
2 İnfectious Diseases and Clinical Microbiology Department, Çorlu State Hospital Tekirdağ, Tekirdağ, Turkey
3 Department of Family Medicine, Medical Faculty of Tekirdağ Namık Kemal University, Tekirdağ, Turkey
4 Medical Microbiology Department, Medical Faculty of Tekirdağ Namık Kemal University, Tekirdağ, Turkey
5 Medical Biochemistry Department, Cerrahpaşa Medical Faculty of İstanbul University, İstanbul, Turkey

Correspondence Address:
Dr. A Celikkol
Medical Faculty of Tekirdağ Namık Kemal University, Clinical Biochemistry Department, Değirmenaltı mah. Kampüs cad. 59030 Süleymanpaşa/Tekirdağ
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njcp.njcp_1633_21

Rights and Permissions

Background: In coronavirus disease 2019 (COVID-19) caused by SARSCoV2 viruses, coagulation abnormalities are strongly correlated between disease severity and mortality risk. Aims: The aim was to search for new indices to determine mortality risk. Fibrinogen times D-dimer to albumin times platelet ratio calculated with the formula (FDAPR index: ((Fibrinogen × D-dimer)/(Albumin × Platelet)) investigated as a mortality marker in COVID-19 patients. The hospitalization data of 1124 patients were analyzed from the electronic archive system. Hemogram, coagulation, and inflammatory markers were investigated in the study group. Materials and Methods: All statistical analyses like the student t-test, Mann–Whitney U, Kaplan–Meier, and Cox hazard ratio, were performed with the SPSS 22.0 program. Results: Prothrombin time was prolonged significantly in patients (P < 0.05) compared to healthy subjects (n = 30). D-dimer and fibrinogen were high, and albumin and platelet counts were low in COVID-19 patients (all, P < 0.001). When the data of 224 non-survivors and 900 survived patients were compared, D-dimer and fibrinogen were higher, and albumin and platelet lower (all, P < 0.001) compared to mild and severe patients. At the cut-off value of 0.49, the FDAPR index was performed with 89.1% sensitivity and 88.6% specificity. FDAPR index had the highest mortality predictive power (P < 0.01; HR = 5.366; 95% CI; 1.729–16.654). Conclusions: This study revealed that the FDAPR index could be used as a mortality marker of COVID-19 disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed166    
    Printed0    
    Emailed0    
    PDF Downloaded48    
    Comments [Add]    

Recommend this journal