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Year : 2022  |  Volume : 25  |  Issue : 6  |  Page : 855-860

The effect of epidural analgesia added to general anesthesia on systemic immune-inflammation index in radical prostatectomy surgery: A retrospective study

1 Department of Anesthesiology and Reanimation, Tekirdag Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey
2 Department of Urology, Tekirdag Namık Kemal University, Faculty of Medicine, Tekirdag, Turkey

Correspondence Address:
Dr. A Gultekin
Tekirdağ Namık Kemal University Faculty of Medicine, Department of Anesthesiology and Reanimation, 2nd Floor Operating Room, Süleymanpasa, Tekirdag
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_1858_21

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Background: Systemic immune-inflammation index (SII) is increasingly valued for its simplicity and predictability. Anesthesia/analgesia technique may affect cancer survey. Aims: The primary aim of this study is to offer a comparative evaluation for the effect of different anesthesia/analgesia techniques employed in radical prostatectomy surgery on SII, a new inflammatory index. Patients and Methods: Eighty-one patients who underwent radical prostatectomy between January 1, 2012, and December 31, 2020, were included in the study. We recorded oncological demographic data of Group G (n = 45) and Group GE (n = 36), preoperative and postoperative (within the first 4 hrs and 24th hr) SII values, perioperative surgical bleeding, and amount of blood transfusion. Results: Despite the lack of significant difference in the SII values between the groups, both the peak SII level and the SII change in the postoperative period became higher in Group G than in Group GE. In addition, the amount of surgical bleeding and blood transfusion was observed to be significantly lower in Group GE (P < 0.001, P = 0.092, respectively). Conclusions: GE in radical prostatectomy surgery in terms of SII, the SII change in the postoperative period was more pronounced in Group G. However, a significant difference was noted in surgical bleeding in Group GE. We can conclude that comparing the SII values of different anesthesia techniques with prospective studies might thus create a difference in survival and metastasis at the micro-level.

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