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Year : 2022  |  Volume : 25  |  Issue : 6  |  Page : 747-764

Plant-derived compounds for the treatment of schistosomiasis: Improving efficacy via nano-drug delivery

1 Department of Medical Biochemistry and Molecular Biology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
2 Department of Chemical Sciences (Biochemistry Programme), Coal City University Enugu, Enugu State, Nigeria
3 Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

Correspondence Address:
Dr. E C Ossai
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_1322_21

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Schistosomiasis is a neglected infectious tropical disease that is second in occurrence only to hookworm infection in sub-Saharan Africa. Presently, chemotherapy is the main method of control and treatment of this disease due to the absence of a vaccine. However, Praziquantel, which is the only chemotherapeutic option, lacks efficacy against the early developmental stages of schistosomes. A number of plant-derived compounds, including alkaloids, terpenes and phenolics, have displayed in vitro and in vivo efficacy against Schistosoma species. This review explores how the application of nanotechnology can improve the efficacy of these plant-derived schistosomicidal compounds through the use of nano-enabled drug delivery systems to improve bioavailability.

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