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Year : 2022  |  Volume : 25  |  Issue : 11  |  Page : 1812-1815

Do the Covid-19 vaccines affect the reproductive parameters of men?—A Northern Saudi experience

1 Department of Surgery, Jouf University, Sakaka, Saudi Arabia
2 Department of Urology, Prince Mutaib Bin Abdulaziz Hospital, Sakaka, Saudi Arabia
3 Department of Radiology, Ministry of Health, Alqurrayat, Saudi Arabia
4 Medical Student, College of Medicine, Jouf University, Sakaka, Saudi Arabia

Correspondence Address:
Dr. M J Alenzi
Department of Surgery, College of Medicine, Jouf University, P.O. Box-72388
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_188_22

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Background: The COVID-19 vaccine acceptance is a psychological behavior influenced by many factors, including fear of an adverse effect on the reproductive system. Aims: The aim of this study is to assess the COVID-19 vaccines effect on reproductive parameters among the male population of northern Saudi Arabia. Patients and Methods: We conducted a prospective cohort study among 100 volunteers who received two doses of COVID-19 vaccines. A pre- and post-vaccination blood sample was collected and analyzed for testosterone, prolactin, and follicle-stimulating hormone (FSH). Semen samples were also collected and analyzed. The Wilcoxon signed-rank test was used to compare the values between pre- and post-vaccination. Results: Of the 100 samples analyzed, there was a significant increase in progressive sperm motility after the second dose of vaccination, but the increase was within the physiological limits (pre-55.03 [42.00–61.75] vs. post-57.50 [42.25–63.00], P = 0.008). Similarly, a significant increase in serum testosterone level after the second vaccination dose was observed (pre-380.65 [301.60–485.73] vs. post-410 [318.18–505.35], P = 0.016). Conclusion: These preliminary results show that the COVID-19 vaccines do not have any adverse effect on the reproductive parameters of men. A prospective long-term follow-up study will be necessary on all WHO -approved COVID vaccines to determine their long-term effect on men's reproductive health. The future follow-up study could strengthen our findings and encourage the men who have vaccine hesitancy to take due to fear of its effect on reproductive parameters.

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