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ORIGINAL ARTICLE
Year : 2018  |  Volume : 21  |  Issue : 7  |  Page : 894-900

Midkine levels and its relationship with atherosclerotic risk factors in essential hypertensive patients


1 Department of Medical Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
2 Department of Medical Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey
3 Department of Family Physician, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
4 Department of Biophysics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
5 Department of Medical Biochemistry, Silivri Anatolia Hospital, Istanbul, Turkey
6 Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey
7 Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
8 Department of Biophysics, Faculty of Medicine, Sakarya University, Sakarya, Turkey

Correspondence Address:
Prof. F B S Cinemre
epartment of Medical Biochemistry, Faculty of Medicine, Sakarya, University, Adapazari, Sakarya 54290
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njcp.njcp_309_17

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Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 ± 6.8 ng/mL vs. 18.39 ± 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 ± 34.06 μg/dL and 172.55 ± 45.47μg/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B12levels (r = −0.298, P < 0.023, r = −0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.


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