Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 357   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2018  |  Volume : 21  |  Issue : 1  |  Page : 63-68

Association between the oxidative status, Vitamin D levels and respiratory function in asthmatic children

1 Department of Pediatric Allergy and Immunology, Samsun Training and Research Hospital, Samsun, Turkey
2 Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
3 Department of Pediatrics, Samsun Training and Research Hospital, Samsun, Turkey
4 University of Health Sciences, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey

Correspondence Address:
Dr. G Karatekin
University of Health Sciences, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_373_16

Rights and Permissions

Aim: We studied the relationship between plasma concentrations of oxidative system markers, vitamin D, and respiratory functions in children with asthma. Materials and Methods: Ninety one children aged 6–17 years with stable asthma seen in the clinic had the serum concentrations of oxidative system markers [total antioxidant capacity (TAC), total oxidative status (TOS), paraoxonase-1 activity (PON-1), and 25-hydroxyvitamin D3] and respiratory functions were measured. Results: There was no statistical correlation between TAC and age and FEV1. There was a significant positive correlation between TAC and 25(OH)D3 (r = 0.214, P = 0.021), TAC and TOS (r = 0.218, P = 0.007), TAC and PON-1 (r = 0.230, P = 0.028), TAC and IgE (r = 0.194, P = 0.033), and inverse correlation between TAC and PEF (r = −0.208, P = 0.024). In the backward multiple regression analysis, 25(OH)D3 (t = 2.613, P = 0.011), age (t = −2.158, P = 0.034), TOS (t = 2.158, P = 0.000), and OSI index (t = −13.859 P = 0.000) maintained an independent relationship with TAC (r = 0.858, r2 = 0.737, F = 21.436, P = 0.000). Conclusion: Oxidative stress correlates with the serum vitamin D concentrations. Clinical trials are required to confirm that increasing serum 25OHD may improve asthma control, as measured by clinical and oxidative stress markers.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded307    
    Comments [Add]    

Recommend this journal