Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 1188   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

  Table of Contents 
Year : 2017  |  Volume : 20  |  Issue : 4  |  Page : 427-432

Effects of 810-nanometer diode laser as an adjunct to mechanical periodontal treatment on clinical periodontal parameters and gingival crevicular fluid volume of residual periodontal pockets

1 Department of Periodontology, Faculty of Dentistry, Istanbul Aydin University, Istanbul, Turkey
2 Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey

Date of Acceptance18-Jan-2016
Date of Web Publication13-Apr-2017

Correspondence Address:
Dr. S E Meseli
Izzettin Calislar Cd. No: 31/2, Bahcelievler, Istanbul
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1119-3077.181382

Rights and Permissions

Background: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume of the residual pockets diagnosed following initial periodontal treatment in chronic periodontitis (CP) patients. Materials and Methods: A total of 84 residual pockets on single-rooted teeth in 11 CP patients were included and randomly assigned into three groups. Residual pockets were treated either only by mechanical treatment (Group M) (n = 28) or only by diode laser disinfection (Group L) (n = 28) or by a combination of these techniques (Group M + L) (n = 28). Plaque index, gingival index (GI), bleeding on probing (BoP), probing depth (PD), clinical attachment level and gingival recession were assessed at baseline and 8 weeks after treatment of residual pockets. GCF samples were collected at baseline, 1 and 8 weeks after treatment. Results: All treatment modalities resulted in significant reductions in PD and attachment gain. GI and BoP showed a greater reduction in both Group M and Group M + L than Group L (P < 0.001), but there was no difference between the Groups M and M + L (P > 0.05). No difference was also found among groups for other clinical parameters. GCF volume decreased significantly in the Groups M and M + L (P < 0.05) but there was no difference among the groups (P > 0.05). Conclusion: Results demonstrated clinical improvements on residual pockets in CP patients treated with all three modalities. Moreover, our findings suggest that application of diode laser as an adjunct to mechanical periodontal treatment doesn't demonstrate any additional clinical effect on the residual pockets.

Keywords: Chronic periodontitis, dental scaling, gingival crevicular fluid, lasers, periodontal pocket, root planing

How to cite this article:
Meseli S E, Kuru B, Kuru L. Effects of 810-nanometer diode laser as an adjunct to mechanical periodontal treatment on clinical periodontal parameters and gingival crevicular fluid volume of residual periodontal pockets. Niger J Clin Pract 2017;20:427-32

How to cite this URL:
Meseli S E, Kuru B, Kuru L. Effects of 810-nanometer diode laser as an adjunct to mechanical periodontal treatment on clinical periodontal parameters and gingival crevicular fluid volume of residual periodontal pockets. Niger J Clin Pract [serial online] 2017 [cited 2022 Dec 8];20:427-32. Available from:

   Introduction Top

Chronic periodontitis (CP) is a periodontal disease seen in the early adulthood and characterized with spontaneous or provoked gingival bleeding, migration, and mobility of teeth, attachment and alveolar bone loss.[1] Initial periodontal treatment (IPT) consists of oral hygiene instructions, scaling and root planing and is the first step for the treatment of all kinds of periodontal diseases. Mild forms of periodontal diseases can be taken under control with IPT. However, in advanced cases, the efficacy of IPT is restricted due to deep periodontal pockets, incomplete elimination of colonized periodontal pathogens from deep periodontal pockets and invasion of these microorganisms into gingival connective tissue.[2],[3]

Periodontal pockets with probing depth (PD) ≥5 mm and bleeding on probing (BoP) (+) after active periodontal therapy are defined as residual periodontal pockets.[4],[5],[6],[7] Residual periodontal pockets carry the risk of recurrence of periodontal disease since they act-like a harbor for periodontal pathogens incompatible with periodontal health.[8] Thus, the elimination of residual pockets is crucial for the treatment of periodontal diseases and maintenance of periodontal health.

Residual pockets can be eliminated with mechanical treatment approaches associated with adjunctive use of local/systemic antimicrobials,[4],[9] photodynamic therapy,[5],[6],[10] and pocket disinfection with lasers.[5],[6] Elimination of residual pockets with adjunctive treatment approaches such as laser disinfection is a novel option, due to lack of relevant studies in the literature.

Laser therapy has been recommended as a novel approach for the treatment of periodontal diseases.[11],[12] A wide spectrum of lasers from CO2 lasers to neodymium-doped:yttrium aluminum garnet (YAG), erbium-doped: YAG, erbium, chromium:yttrium-scandium-gallium-garnet, and diode lasers have been used in dentistry.[11] Lasers demonstrate antibacterial effect due to direct ablation and thermomechanic disruption of bacterial cells.[11]

The diode laser with wavelength between 800 and 980 nm is highly absorbed in hemoglobin and other pigments and has minimal thermal side effects on dental hard tissues.[11] It can be used for the incision and coagulation of oral mucosa and gingiva, pocket disinfection for bacterial elimination, and sulcular curettage.[11] Üstün et al.[13] showed that pocket disinfection with a 810 nm diode laser as an adjunct to scaling and root planing reduced gingival index (GI) better than scaling and root planing alone. Moreover, gingival crevicular fluid (GCF) volumes and interleukin-1β levels in GCF demonstrated higher reductions after combined therapy.[13] Systematic reviews evaluating the potential benefit of laser application over mechanical debridement in nonsurgical periodontal therapy by meta-analysis failed to reach a conclusion due to the lack of comparable data.[14],[15] Hence, the evidence to support the clinical applications of adjunctive diode laser use with mechanical debridement is still inconclusive.

GCF is a blood-originated fluid playing an important determinant role in the ecology of the gingival sulcus and periodontal pocket.[16] While GCF acts as a transudate in healthy periodontium, it becomes an exudate in periodontal inflammation.[17] The increased permeability of blood vessels underlying sulcular and junctional epithelium causes an upsurge in GCF volume.[17],[18]

The purpose of this study was to evaluate the effects of 810 nm diode laser as an adjunct to mechanical periodontal treatment on the clinical periodontal parameters and GCF volume of the residual periodontal pockets diagnosed following IPT in CP patients, and additionally compared this combined treatment approach with mechanical debridement and diode laser individually. The null hypothesis states that there is no difference in the existing outcome variables of residual pockets treated with either combined approach consisting of mechanical periodontal treatment and diode laser or single approach.

   Materials and Methods Top

This prospective study was planned as a single-centered randomized three-arm parallel-designed clinical trial. The duration of the study was 19 weeks. The Clinical Research Ethical Committee of Yeditepe University approved the protocol on November 13, 2012, with the reference number 255. The research was conducted according to the principles outlined in the Declaration of Helsinki on experimentation involving human subjects. This randomized clinical trial was approved by the with the registration number NCT02531555.


Eleven CP patients, recruited consecutively from the Clinics of Periodontology Department, Faculty of Dentistry, Marmara University, were invited to participate in this study. To be eligible for the study, the volunteer had to present the following inclusion criteria: Systemically healthy, nonsmoker, CP diagnosed according to Armitage,[1] aged between 35 and 65, not received any periodontal treatment within the last 3 months have horizontal bone loss radiographically, presence at least 20 natural teeth except third molars and consent to participate in the study. The exclusion criteria were as follows: Any systemic disease that might interfere with the prognosis of periodontal disease (i.e., diabetes mellitus, HIV infection), smoking, antibiotics, anti-inflammatory drugs or any other medication taken within the last 6 months that might affect the outcome of the study, any physical limitations or restrictions that might preclude normal oral hygiene procedures. Written informed consent was obtained from all participants.

IPT that includes oral hygiene instructions, scaling and root planing was applied to all subjects with ultrasonic (Cavitron® BOBCAT® Pro, Dentsply International, USA) and hand instruments (Gracey, SG 5/6, 7/8, 11/12, 13/14, Hu-Friedy Ins. Co., USA) in two sessions with a 1-week interval. Eight weeks after IPT, residual periodontal pockets demonstrating PD ≥5 mm and BoP (+) on single-rooted teeth were selected for this study.

The sample size was chosen based on clinical considerations.[19] Assuming that the common standard deviation for PD is 1 mm, a sample of 28 residual pockets per group would provide 80% power to detect a true difference of 0.75 mm among groups.

Study groups and randomization

Selected residual periodontal pockets were randomly assigned by a computer-generated table to receive one of the following three treatment modalities. Residual pockets present in the same patient were appointed into randomization table on clockwise direction starting from the pocket, which was located the most distal position of the maxillary right quadrant. Moreover, special attention was paid that each residual pocket was separated from another with at least one interdental papilla site.

The treatment groups in this study are as follows:

Mechanical periodontal treatment (Group M): Scaling and root planing were performed with ultrasonic and hands instruments until the operator feels that root surface is clean, hard and smooth

Pocket disinfection with a diode laser (Group L): Subgingival irradiation with a GaAlAs diode laser (CHEESE®, Gigaa Laser, China) was applied to residual pockets each for 20 s in continuous mode. The diode laser had a wavelength of 810 nm and power output of 1 W for subgingival irradiation (maximum output power of device was 7 W). Diode laser application was performed parallel to root surface by a 200 µm fiber tip inserted at the bottom of periodontal pocket and slowly moved from apical to coronal direction in a sweeping motion without local anesthesia

Combined treatment (Group M + L): Following mechanical periodontal treatment, pocket irradiation with diode laser was performed as mentioned above.

Clinical protocol

In the first session, all subjects went through detailed systemic and dental anamneses and received radiographical and periodontal examination. After 1-week, all subjects received IPT consisting oral hygiene instructions and supra/subgingival scaling and root planing applied with ultrasonic and hand instruments in two sessions with a 1-week interval. Eight weeks following the completion of IPT, periodontal pockets demonstrating PD ≥5 mm and BoP (+) on single-rooted teeth were selected as residual periodontal pockets, which were randomly assigned to three treatment groups.

The first session of treatment for residual pockets was accepted as a baseline of this study [Figure 1]. In this session, GCF samples were collected from the residual pockets, clinical periodontal parameters were recorded, and treatment protocols were applied. After 1-week, GCF samples were collected from the same sites, and after 8 weeks, GCF samples were collected, and clinical periodontal parameters were recorded again for the residual pockets.
Figure 1: A residual pocket after initial periodontal treatment

Click here to view

Periodontal examination

Clinical periodontal parameters were evaluated at baseline and, 8 weeks after treatment of residual pockets. The measured parameters were plaque index (PI),[20] GI,[21] BoP, PD and clinical attachment level (CAL). PD was defined as the distance from the free gingival margin to the bottom of the periodontal pocket. CAL was defined as the distance from the cementoenamel junction to the bottom of the periodontal pocket. PD and BoP were the primary outcomes of this study.

All clinical examinations were carried out by a single examiner (standard error of mean). To achieve the intra-examiner calibration, five nonstudy subjects were selected, and full mouth PD scores were measured twice within 3 days. The intra-examiner correlation was calculated as 94.8% reproducibility.

Gingival crevicular fluid collection and volume calculation

GCF samples were collected from the residual pockets at baseline, 1 and 8 weeks after treatment. To prevent plaque and saliva contamination, supragingival plaque was gently removed and cotton rolls were placed in the vestibular and lingual sites of selected pockets.[17] Moreover, all saliva was aspirated from the mouth and sampling site. A prefabricated paper strip (Periopaper, Oraflow Inc., Smithtown, NY, USA) was gently inserted just at the entrance of pocket[22] and then left there for 30 s. Strips visibly contaminated with blood, saliva or microbial dental plaque were discarded. The GCF volume was measured with a calibrated Periotron 8000 (OraFlow, Inc., Smithtown, NY, USA) and then numerical readings were converted into actual volume (µl) with the reference to formulation obtained from the standard curve.

Statistical analyses

The statistical analysis was performed using SPSS 20 (SPSS Corporation, Chicago, IL, USA) with a significance level of 5%.

The Kolmogorov–Smirnov test was used to check the distribution for normality. Repeated measurements of clinical parameters and qualitative variables were analyzed with Wilcoxon signed rank test. Repeated measurements of GCF volumes were analyzed with Friedman test.

The Kruskal–Wallis analyses, the Mann–Whitney U-test, and Chi-square and Fisher's exact test were used to determine differences among the groups.

   Results Top

The study population consisted of 11 CP patients with the mean age of 44.09 ± 4.48 years (range 37–51). A total of 84 residual periodontal pockets on single-rooted teeth in these patients were included in each group having 28 residual pockets. Distributions of these residual pockets on the patients are shown in [Table 1].
Table 1: Distribution of residual pockets in 11 patients

Click here to view

[Table 2] displays the clinical periodontal findings of residual pockets at baseline and 8 weeks after treatment. At baseline, there was no difference among the groups regarding clinical parameters, as expected. All clinical parameters, except PI, showed significant improvements after treatment in the Group M and the Group M + L (P < 0.001), but in the Group L only PD (P < 0.001) and CAL (P < 0.03) showed significant improvements. GI and BoP of the Group M and the Group M + L demonstrated greater reduction than those of the Group L (P < 0.001), however, there was no difference between the Groups M and M + L (P > 0.05). No difference was found among the groups for the other clinical parameters after treatment. Before treatment, all experimental sites demonstrated PD equal or deeper than 5 mm and presented BoP. Approximately, 14% of the sites in the Group M, 50% of the sites in the Group L and 11% of the sites in the Group M + L still had PD ≥5 mm and BoP (+), which means they remained residual [Table 3]. The number of residual pockets in the Group L was significantly higher than those of the other two groups after treatment (P < 0.001) [Table 3]. At the end of the study period, a quarter of all sites were still residual independent from the treatment modality. The risk of a site to remain residual was approximately 5 times higher after treatment with diode laser alone compared with the other treatment approaches [Table 3].
Table 2: Intragroup and intergroup analyses of clinical findings at baseline and after 8 weeks

Click here to view
Table 3: Number and percentage of residual pockets in each treatment group at baseline and after 8 weeks

Click here to view

GCF volume decreased statistically significantly after treatment in the Groups M and M + L (P < 0.05) but showed no difference among the groups at all time points (P > 0.05) [Table 4]. When the changes in GCF volume between different sample collection times of the groups were compared, the differences were also insignificant, as shown in [Table 5] (P > 0.05).
Table 4: Gingival crevicular fluid volume

Click here to view
Table 5: Changes in gingival crevicular fluid volume between different collection time points

Click here to view

   Discussion Top

Residual pockets represent a risk factor as they harbor periodontal pathogens that may cause initiation and progression of periodontitis which may result in tooth loss,[7] Therefore, it is necessary to take the residual pockets under control for the maintenance of periodontal health status. Residual pockets are the sites requiring additional therapeutic approaches.[10] To our knowledge, this is the first study evaluating clinical effects of 810 nm diode laser as an adjunct to mechanical periodontal treatment of residual pockets diagnosed after IPT.

The findings of presented study showed significant improvements in GI and BoP parameters achieved with both mechanical treatment alone and mechanical treatment combined with adjunctive use of diode laser, without any difference between these two approaches. Similarly, the percentages of the remaining residual pockets were significantly lower in the Group M and Group M + L 8 weeks after treatment, without any significant difference between them. Significant reduction in PD and attachment gain were obtained in all three-treatment approaches, without any differences among groups.

A positively directed association between GCF volume and gingival inflammation has been declared previously.[16],[18] In this study, GCF volume decreased parallel to the declines in GI and BoP in the Group M and M + L.

Similar to our study, Üstün et al.[13] used 810 nm wavelength diode laser as an adjunct to mechanical treatment for 20 s/site. Adversely to ours, results of this study had better clinical outcomes with combined approach on GI, PD and CAL and GCF volume than mechanical treatment alone. Nevertheless, diode laser was used as adjunct to nonsurgical treatment on untreated sites of CP patient in that study.[13] It must be noticed that clinical improvement of residual pockets is limited and more difficult than the untreated periodontal sites.

So far, only two clinical trials have been published on the treatment of residual pockets in periodontology literature with similar study groups and designs.[5],[6] In contrast with our study, both studies showed that pocket irradiation with diode laser and mechanical treatment alone had similar effects on the reductions of GI and BoP. However, residual pockets detected during maintenance phase 3–24 months after completion of comprehensive periodontal treatment were included in these abovementioned studies.[5],[6] Therefore, included residual pockets, to these two studies may contain more pathogenic microorganisms that resulted in higher gingival inflammation to give a better response to pocket irradiation with a diode laser. Giannopoulou et al.[5] investigated levels of several cytokines and acute-phase proteins in GCF after treatment of residual pockets with diode laser pocket irradiation. Although, GCF volumes were not presented, levels of cytokines, and acute-phase proteins decreased significantly after treatment with diode laser application.

Selection of laser parameters correctly is significant to avoid thermal side effects. To be effective, each laser system has its own application parameters in different treatment modalities. In this study, 810 nm wavelength diode laser (1.0 W, 20 s/pocket) was applied to residual pocket parallel to the root surface in a sweeping motion like a scanning without local anesthesia. There were no feedbacks from patients about side effects related to laser application, such as burning sensation and pain with these laser settings and application technique. There were some clinical trials assessing adjunctive effect of laser irradiation to IPT that applied in longer than 20 s/pocket,[23],[24] repeatedly applied in one session[24] or applied more than one session.[25] Consequently, longer application times or repeated applications of diode laser pocket irradiation for treatment of residual pockets can be evaluated in further studies.

Within the limitations of this study, the results of this clinical trial demonstrated that the 810 nm wavelength diode laser as an adjunct to mechanical treatment on residual pockets of CP patients is not superior to mechanical treatment alone. In addition, diode laser application alone has limited effects on clinical periodontal parameters of residual pockets. Since only a few clinical trials exist about the treatment of residual pockets, additional longitudinal, randomized, and controlled clinical trials are necessary to test the potential benefits of adjunctive of a diode laser to mechanical treatment of residual pockets. Future clinical trials supported with microbiological and biochemical variables to correlate with the clinical outcomes should be designed using 810 nm wavelength diode laser testing different application times and/or repeated, multiple applications.

   Conclusion Top

Our research demonstrates that diode laser application as an adjunct to mechanical treatment of residual pockets appears to have no additional effect on clinical parameters and GCF volume.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.  Back to cited text no. 1
Socransky SS, Haffajee AD, Effect of therapy on periodontal infections. J Periodontol 1993;64(Suppl 8):754-9.  Back to cited text no. 2
Cobb CM. Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996;1:443-90.  Back to cited text no. 3
Feng HS, Bernardo CC, Sonoda LL, Hayashi F, Romito GA, De Lima LA, et al., Subgingival ultrasonic instrumentation of residual pockets irrigated with essential oils: A randomized controlled trial. J Clin Periodontol 2011;38:637-43.  Back to cited text no. 4
Giannopoulou C, Cappuyns I, Cancela J, Cionca N, Mombelli A. Effect of photodynamic therapy, diode laser, and deep scaling on cytokine and acute-phase protein levels in gingival crevicular fluid of residual periodontal pockets. J Periodontol 2012;83:1018-27.  Back to cited text no. 5
Cappuyns I, Cionca N, Wick P, Giannopoulou C, Mombelli A. Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial. Lasers Med Sci 2012;27:979-86.  Back to cited text no. 6
Matuliene G, Pjetursson BE, Salvi GE, Schmidlin K, Brägger U, Zwahlen M, et al. Influence of residual pockets on progression of periodontitis and tooth loss: Results after 11 years of maintenance. J Clin Periodontol 2008;35:685-95.  Back to cited text no. 7
Mombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia nigrescens, and Actinobacillus actinomyetemcomitans after mechanical therapy of periodontal disease. J Periodontol 2000;71:14-21.  Back to cited text no. 8
Mendonça AC, Santos VR, Ribeiro FV, Lima JA, Miranda TS, Feres M, et al. Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: A pilot study. J Clin Periodontol 2012;39:368-76.  Back to cited text no. 9
Campos GN, Pimentel SP, Ribeiro FV, Casarin RC, Cirano FR, Saraceni CH, et al., The adjunctive effect of photodynamic therapy for residual pockets in single-rooted teeth: A randomized controlled clinical trial. Lasers Med Sci 2013;28:317-24.  Back to cited text no. 10
Aoki A, Sasaki KM, Watanabe H, Ishikawa I, Lasers in nonsurgical periodontal therapy. Periodontol 2000-2004;36:59-97.  Back to cited text no. 11
Ishikawa I, Aoki A, Takasaki AA, Mizutani K, Sasaki KM, Izumi Y. Application of lasers in periodontics: True innovation or myth. Periodontol 2000-2009;50:90-126.  Back to cited text no. 12
Üstün K, Erciyas K, Sezer U, Senyurt SZ, Gündogar H, Üstün Ö, et al. Clinical and biochemical effects of 810 nm diode laser as an adjunct to periodontal therapy: A randomized split-mouth clinical trial. Photomed Laser Surg 2014;32:61-6.  Back to cited text no. 13
Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: A systematic review. J Clin Periodontol 2008;35(Suppl 8):29-44.  Back to cited text no. 14
Karlsson MR, Diogo Löfgren CI, Jansson HM. The effect of laser therapy as an adjunct to non-surgical periodontal treatment in subjects with chronic periodontitis: A systematic review. J Periodontol 2008;79:2021-8.  Back to cited text no. 15
Goodson JM. Gingival crevice fluid flow. Periodontol 2000-2003;31:43-54.  Back to cited text no. 16
Kuru L, Kirby AC, Griffiths GS, Petrie A, Olsen I. Changes in soluble adhesion molecules in gingival crevicular fluid following periodontal surgery. J Periodontol 2005;76:526-33.  Back to cited text no. 17
Griffiths GS. Formation, collection and significance of gingival crevice fluid. Periodontol 2000-2003;31:32-42.  Back to cited text no. 18
Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002;29:Suppl 3136-59.  Back to cited text no. 19
Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:121-35.  Back to cited text no. 20
Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.  Back to cited text no. 21
Loe H, Holm-Pedersen P. Absence and presence of fluid from normal and inflamed gingivae. Periodontics 1965;3:171-7.  Back to cited text no. 22
Yilmaz S, Kuru B, Kuru L, Noyan U, Argun D, Kadir T. Effect of gallium arsenide diode laser on human periodontal disease: A microbiological and clinical study. Lasers Surg Med 2002;30:60-6.  Back to cited text no. 23
Caruso U, Nastri L, Piccolomini R, d'Ercole S, Mazza C, Guida L. Use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. A randomized controlled clinical trial. New Microbiol 2008;31:513-8.  Back to cited text no. 24
Euzebio Alves VT, de Andrade AK, Toaliar JM, Conde MC, Zezell DM, Cai S, et al., Clinical and microbiological evaluation of high intensity diode laser adjutant to non-surgical periodontal treatment: A 6-month clinical trial. Clin Oral Investig 2013;17:87-95.  Back to cited text no. 25


  [Figure 1]

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]

This article has been cited by
1 Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials
Magdalena Pawelczyk-Madalinska,Stefano Benedicenti,Tudor Salagean,Ioana Roxana Bordea,Reem Hanna
Journal of Inflammation Research. 2021; Volume 14: 2515
[Pubmed] | [DOI]
2 Effectiveness of an 810-nm Diode Laser in Addition to Non-surgical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Single-Blind Clinical Trial
Majid Reza Mokhtari,Farzaneh Ahrari,Shokoufeh Dokouhaki,Amir Fallahrastegar,Alireza Ghasemzadeh
Journal of Lasers in Medical Sciences. 2021; 12(1): e37
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Materials and Me...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded535    
    Comments [Add]    
    Cited by others 2    

Recommend this journal